Alex loukas parasitology pdf

Brindleyc, adepartment of parasitology, faculty of medicine, khon kaen university, khon kaen 40002, thailand bdivision of infectious diseases and immunology, queensland institute of medical research, brisbane. When only two groups were compared, a mannwhitney test was used. Jeffrey bethony, simon brooker, marco albonico, stefan m geiger, alex loukas, david diemert, peter j hotez. Interestingly, earlier publications aimed at characterising the es products of adult schistosomes described the presence of proteins that were typically thought of as intracellular in location perezsanchez et al. Mobile genetic elements colonizing the genomes of metazoan.

Introduction professor nick smith, convenor, arcnhmrc research network for parasitology. Citescore values are based on citation counts in a given year e. Molecular characterisation of the ancylostomasecreted protein family from the adult stage of ancylostoma caninum. The latest evidence confirms that blood loss caused by the worms feeding activity in the gut is a contributing factor in the development of poor iron status leading to irondeficiency anaemia. Bethony2 and alex loukas3 1department 2 ofpathology, faculty medicine, khonkaen university, kaen, 40002 thailand. Paul prociv immune responses in hookworm infections. Infection with the foodborne liver fluke opisthorchis viverrini causes cholangiocarcinoma cca. The mechanisms by which the parasite causes cancer are complex, but a role for excessive wound healing in response to feeding parasites in the bile ducts has been proposed. A large part of oceanias population lives in poverty and therefore is at. Infections with several flatworm parasites represent group 1 biological carcinogens, i. Alex loukas australian institute of tropical health and medicine, james cook university, cairns, australia for correspondence alex. Neglected tropical diseases oceania alex loukas springer. An orthologue of granulin from the human parasitic liver fluke opisthorchis viverrini, known as ovgrn1, induces angiogenesis and accelerates wound repair. The fugitive ltr retrotransposon from the genome of the human blood.

Hookworm recombinant protein promotes regulatory t cell. Whereas the causative agent for most cancers, including cca in the west, remains obscure, the principal risk factor for cca in thailand is opisthorchiasis. Nature research makes no representations, warranties or guarantees, whether express or implied, that the content on this community is accurate, complete or up to date, and to the fullest extent permitted by law all liability is. Caffrey returned to ucsf in 2001 to direct the biochemistry and molecular parasitology core of the sandler center the sandler center for basic research in parasitic diseases now the sandler center for drug discovery.

Changed gluten immunity in celiac disease by necator americanus. Hookworm infection is a major neglected tropical disease that causes substantial disability and iron deficiency anaemia in atrisk populations. The sra is a comprehensive, wellorganized list of research activities that reflects the impressive diversity of interests. Sp spring onference the british society for parasitology. The international journal for parasitology publishes the results of innovative basic and applied findings in all aspects of parasitology. Human enteric infection with canine hookworms annals of. Alex loukas helminths facilitate their parasitic existence through the production and secretion of different molecules, including proteins. International journal for parasitology icopa xii icopa. Some helminth proteins can manipulate the hosts immune system, a phenomenon that is now being exploited number with a view to developing therapeutics for in. The journal focuses on general parasitology, as well as parasites of medical, veterinary, and economic importance.

The australian society for parasitology inc pages 1 40. Despite the existence of the highly effective antischistosome drug praziquantel pzq. Pdf textbook of medical parasitology, protozoology. Identification of potential protective antigens of. Author summary the oriental liver fluke opisthorchis viverrini infects millions of people in seasia and kills 26,000 people each year due to parasiteinduced liver cancer. Interestingly, earlier publications aimed at characterising the es products of adult schistosomes described the presence of proteins that were typically thought of as intracellular in location perezsanchez et. Granulins are a family of protein growth factors that are involved in cell proliferation. Asp secretariat, c rgsq 237 milton road milton qld 4064 name as it appears on present mailing label. International journal for parasitology 37 34, 257263, 2007. Current status of vaccines for schistosomiasis clinical. This volume of the neglected tropical diseases ntd series covers the most prevalent ntds in oceania. Recent molecular and biochemical parasitology articles.

Development of a potent wound healing agent based on the. Malaghan institute for medical research, wellington nz, james hewitson university of york, alex loukas james cook university, cairns, australia, danielle smyth university of glasgow, rick maizels university of glasgow, judi allen university of manchester, john grainger. Zhan, bin liu, yueyuan badamchian, mahnaz williamson, angela feng, jianjun loukas, alex hawdon, john m and hotez, peter j 2003. Natthawut kaewpitoon, thewarach laha, sasithorn kaewkes, puangrat yongvanit, paul j. Pdf the hookworm pharmacopoeia for inflammatory diseases. Icopa xii icopa xii 1520 august 2010 melbourne convention and exhibition centre mcec edited by alex loukas.

Volume 40, issue 10, pages 11071228 15 august 2010 download full issue. Recombinant ovgrn1 production is complex and poses an obstacle for clinical development. Bethony is in the department of microbiology, immunology and tropical medicine, george washington university, 2300 eye street northwest, washington, dc. Hookworm secreted extracellular vesicles interact with host cells. All results stated in the text are means the standard errors of the mean sem. Exploiting helminthhost interactomes through big data. While having many common features, they also differ in several key aspects of their.

Javier sotillo, michael smout, watcharapol suyapoh. Infection follows direct contact with freshwater harboring freeswimming larval cercaria forms of the parasite. Parasites have cohabited with humans for thousands of years, and about 300 species of. Past and present maizels lab members gathered at the. Brindley, banchob sripa and thewarach laha, suppression of ovgrn1 encoding granulin of opisthorchis viverrini inhibits proliferation of biliary epithelial cells, experimental parasitology, 10. The two major species are necator americanus, which is adapted to tropical conditions, and ancylostoma duodenale, which predominates in more temperate zones. Asiatic liver fluke from basic science to public health, part b. Programmed mutation of liver fluke granulin using crispr. Campbell, thewarach laha, woonmok sohn, banchob sripa, alex loukas, paul j. Hookworms, bloodfeeding intestinal nematode parasites, are particularly adept at manipulating the immune systems of. The journal of parasitology is the official publication of the american society of parasitologists asp. The immunoepidemiology of human hookworm infection. Parasitology, faculty of medicine, kho n kaen university, khon kaen, thailand. Most downloaded molecular and biochemical parasitology.

Summary schistosomiasis, caused by trematode blood flukes of the genus schistosoma, is recognized as the most important human helminth infection in terms of morbidity and mortality. International journal for parasitology 43 20 225231 contents lists available at sciverse sciencedirect. The excitement stems from the 2 year commitment by the. John croese, mb, bs, 42 ross river road, mundingburra, townsville, queensland, 4812 australia. While having many common features, they also differ in several key aspects of their biology. Alex loukas nature research microbiology community. I obtained a bsc hons in 1990 and a phd in 1995 from university of queensland in the field of immunoparasitology. Terrence mulhearn and neil walker for referral of a patient and associate professor rick speare for assistance with identification and measurement of parasites patients 4 and 8. Mcmanus3 and alex loukas4 1dept of tropical medicine, tulane university, health sciences center, new orleans, louisiana, 70112, usa.

Brindley2, jason mulvenna3, thewarach laha4, michael j. Hookworm infection elicited not only parasitespecific immunity but also modified the hosts immune response to gluten. Liver fluke infection caused by opisthorchis viverrini is a major public health problem in thailand and adjacent countries. Suppression of mrnas encoding cd63 family tetraspanins. Gaze and alex loukas, changed gluten immunity in celiac disease by necator americanus provides new insights into autoimmunity, international journal for. Mobile genetic elements colonizing the genomes of metazoan parasites paul j. Hookwormderived metabolites suppress pathology in a mouse. The success of the network is due to the energy, time and commitment of every participant but several deserve special thanks for their efforts in 2008. Hookworm excretorysecretory products induce interleukin4. Speakers program molecular helminthology an integrated. Summary hookworms infect perhaps onefifth of the entire human population, yet little is known about their interaction with our immune system.

Change of addressif you have changed your address, title or name. Alex loukas james ook university george dimopoulos john hopkins university peter hiodini hospital for tropical university of diseases, londonwisconsin giancarlo iagini liverpool school of tropical medicine grace mulcahy university ollege dublin sarah ulloty university ollege ork jane hodgkinson university of liverpool tim yoshinomadison david. An investigation of hookworm infection and reinfection following mass anthelmintic treatment in the south indian fishing community of vairavankuppam volume 96 issue 3 melissa r. Alex loukas 1, 1 centre for biodiscovery and molecular development of therapeutics, australian institute of tropical health and medicine, james cook university, cairns, queensland, australia.

Areas include but are not restricted to human and veterinary medicine, agriculture, ecology and studies on the microbiota in the context of hostparasite relationships. The tumorigenic liver fluke opisthorchis viverrini. In addition to infectionassociated morbidity, infection with o. Download key findings in veterinary parasitology i.

Prof alex loukas research portfolio james cook university. Liver fluke infection caused by opisthorchis viverrini remains a serious public health problem in southeast asia 1. Exploiting helminthhost interactomes through big data cell press. Asiatic liver fluke from basic science to public health. Volume 89 issue 4 journal of parasitology allen press. This book will discuss in detail pathology, diagnostics and control approaches of selected ntds in the geographic region.